Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep584 | Endocrine-Related Cancer | ECE2022

Genes involved in chromatin-remodeling complex could alter the regulation of alternative splicing in lungNENs

Agraz-Doblas Antonio , Blazquez-Encinas Ricardo , Garcia Vioque Victor , Alcala Nicolas , Sexton Alexandra , Trinidad Moreno Montilla Maria , Alors-Perez Emilia , salamanca jimenez pilar , Foll Matthieu , Cuesta Lynnette Ferna nez , Ibanez Costa Alejandro , P. Castano Justo

Lung neuroendocrine neoplasms (LungNENs) comprise a diverse group of rare tumors with a commonly difficult and late diagnosis, which often require complex management and treatment. The most frequently mutated genes in LungNENs have recently been identified, including known components of the chromatin-regulating pathways such as MEN1, PSIP1 and ARID1A, which are the subject of ongoing detailed studies. In contrast, other key regulatory mechanisms, par...